Research Reproducibility 2016

This conference will feature prominent speakers and opportunities to explore the concept of reproducibility.


Mayden Lecturer
  • Hilda Bastian (NIH)
Featured Speaker
  • David Moher (OHRI)
Snyder Lecturer
  • John Ioannidis (Stanford)
Panel Moderators
  • Thomas Parks (Utah)
  • Melissa Rethlefsen (Utah)
Federal Agency Representatives
  • Lisa McShane (NIH)
  • Kathy Partin (ORI)
  • James Olds (NSF) (withdrawn)
Local Experts
  • Thomas Cheatham (Utah)
  • J. Michael Dean (Utah)
  • Tom Greene (Utah)
  • Mellanye Lackey (Utah)
  • Bernie LaSalle (Utah)
Journal Editors
  • John Carey (Utah)
  • Julie Fritz (Utah)
  • David Grainger (Utah)
  • Patricia Morton (Utah)
Poster Presenters

Priscilla M. Mayden Lecture

Hilda Bastian was a long-time consumer advocate in Australia, whose career turned to analyzing evidence, communicating about it, and working to make it more accessible. Hilda now works at the National Institutes of Health (NIH) in the US, at the National Center for Biotechnology Information (NCBI) in the National Library of Medicine (NLM). She is editor of PubMed-related projects on clinical effectiveness and post-publication evaluation, PubMed Health and PubMed Commons.

She arrived at the NIH in 2011 after 7 years in Germany helping establish IQWiG, a national health technology assessment agency. She was the head of its Department of Health Information. Before that, during the 1990s and 2000s, Hilda was active locally, nationally, and internationally in health consumer groups, including time as the Chairperson of the Consumers’ Health Forum, of which she is an honorary lifetime member. She helped to establish the Cochrane Collaboration, founding and leading its Consumer Network for over a decade. She was the first Coordinating Editor of Cochrane’s Consumer and Communication Review Group.

Hilda is a committed and enthusiast Wikipedian, academic editor of PLOS Medicine, and member of PLOS One’s human research ethics advisory group. She cartoons and blogs about clinical epidemiology, evidence, and uncertainties.

Featured Speaker

David Moher is a senior scientist, Clinical Epidemiology Program, Ottawa Hospital Research Institute, and Associate Professor, School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, where he holds a University Research Chair. Dr. Moher has been recognized twice as one of the most highly influential biomedical researchers in the world by Thomson Reuters (The World's Most Influential Scientific Minds). Boyack and colleagues also recognized Dr. Moher as a highly influential biomedical researcher (A list of highly influential biomedical researchers, 1996-2011. European Journal of Clinical Investigation 2013;43:1339-1365).

One of Dr. Moher’s research foci is journalology (publication science). He spearheaded the development of the CONSORT and PRISMA Statements, and has been involved with several other reporting guideline initiatives. He is leading a program to develop core competencies for medical journal editors. Finally, he is actively developing a program to investigate alternatives to current incentives and rewards in academic medicine.

Dr. Moher is the founding Editor-in-Chief of Systematic Reviews and serves on the editorial boards of several journals; he is a member of PLoS ONE’s Human Research Advisory Group.

The Clifford C. Snyder M.D. & Mary Snyder Lecture

John P.A. Ioannidis (b. New York, NY, 1965) holds the C.F. Rehnborg Chair in Disease Prevention at Stanford University, and he is Professor of Medicine, and of Health Research and Policy, and Director of the Stanford Prevention Research Center at the School of Medicine; Professor of Statistics (by courtesy) at the School of Humanities and Sciences; one of the two Directors of the Meta-Research Innovation Center at Stanford; and Director of the PhD program in Epidemiology and Clinical Research. Ioannidis grew up in Athens, Greece. He was Valedictorian (1984) at Athens College and won many early awards, including the National Award of the Greek Mathematical Society (1984). He graduated (top rank of his medical school class) from the University of Athens in 1990; also received a doctorate in biopathology from the same institution. He trained at Harvard and Tufts (internal medicine and infectious diseases), then held positions at NIH, Johns Hopkins and Tufts. He chaired the Department of Hygiene and Epidemiology at the University of Ioannina Medical School in 1999-2010 (tenured professor since 2003). He has been adjunct faculty for Tufts University since 1996 (professor rank since 2002) and led (2008-2010) the Center for Genetic Epidemiology and Modeling. He has also been adjunct professor of epidemiology at Harvard School of Public Health and visiting professor of epidemiology and biostatistics at Imperial College. He is a member of the executive board of the Human Genome Epidemiology Network and Senior Advisor on Knowledge Integration at NCI/NIH and has served as President, Society for Research Synthesis Methodology, and editorial board member of many leading journals (including PLoS Medicine, Lancet, Annals of Internal Medicine, JNCI, Science Translational Medicine, Clinical Chemistry, Molecular and Cellular Proteomics, AIDS, IJE, JCE, Clinical Trials, and PLoS ONE, among others) and as Editor-in-Chief of the European Journal of Clinical Investigation (2010-now). He has given about 400 invited and honorary lectures, has received many awards (e.g. European Award for Excellence in Clinical Science [2007], Medal for Distinguished Service, Teachers College, Columbia University [2015]), and has been inducted in the Association of American Physicians (2009), European Academy of Cancer Sciences (2010) Americal Epidemiological Society (2015), and European Academy of Sciences and Arts (2015). Honorary titles from the Foundation for Research and Technology-Hellas (FORTH) (2014) and University of Ioannina (2015), honorary doctorate from Erasmus University Rotterdam (2015).

The PLoS Medicine paper on “Why most Published Research Findings are False,” has been the most-accessed article in the history of Public Library of Science (exceeding 1.5 million hits). His books “Toccata for the Girl with the Burnt Face” (Kedros 2012) and “Variations on the Art of the Fugue and a Desperate Ricercar” (Kedros 2014) (both in Greek) were shortlisted for best book of the year Anagnostis awards. The Atlantic selected Ioannidis as the Brave Thinker scientist for 2010 claiming that he “may be one of the most influential scientists alive”. He has published over 800 papers and is one of the most-cited scientists worldwide according to citation databases for which rankings are available (Web of Science/Highly-Cited Researchers, Scopus, Microsoft Academic Search). His current citation rate (>1,800 new citations per month per Google Scholar, >1000 new citations per month per Scopus and Web of Knowledge) places him in the 100 most-cited among all 20+ million authors publishing across science. Citation indices: h=137, m=6.5, hm=81 per Google Scholar (h=113 per ISI and Scopus), 68% of papers as single/first/senior author.

He considers himself privileged to have learnt and to continue to learn from interactions with students and young scientists (of all ages) from all over the world and to be constantly reminded that he knows next to nothing.

Panel Moderators

Thomas N. Parks, Ph.D. is Emeritus Professor of Neurobiology & Anatomy at the University of Utah School of Medicine. He was the university’s Vice President for Research and President of its Research Foundation from 2008-2016 and the George & Lorna Winder Professor of Neuroscience and Chair of his department from 1992-2007. His research on the developing auditory system was continuously funded by the NIH for 26 years and he taught neuroscience to medical and graduate students for 30 years. Dr. Parks was a co-founder of NPS Pharmaceuticals Inc. and a board member from 1986-2006.



Melissa Rethlefsen is the Deputy Director of the Spencer S. Eccles Health Sciences Library at the University of Utah in Salt Lake City, UT. Previous to her position at the University of Utah, she worked at the University of Minnesota Bio-Medical Library, the Minnesota Department of Health R.N. Barr Library, and the Mayo Clinic. An avid writer and researcher, she has written dozens of articles for magazines and journals, including five research papers in the Journal of the Medical Library Association and her most recent article, “Librarian co-authors correlated with higher quality reported search strategies in general internal medicine systematic reviews,” in Journal of Clinical Epidemiology. She is also lead author of the book, Internet Cool Tools for Physicians. In 2015, she was awarded the Estelle Brodman Award for Academic Medical Librarian of the Year. Her current research is on systematic review methodology and bibliometrics.

Federal Agency Representatives

Lisa Meier McShane, Ph.D. is a Mathematical Statistician and Chief of the Biostatistics Branch in the Biometric Research Program in the Division of Cancer Treatment and Diagnosis (DCTD) at the U.S. National Cancer Institute (NCI). Dr. McShane advises programs in DCTD and NCI on matters relating to development and use of tumor markers for prognosis, therapy selection, and disease monitoring. She holds a Ph.D. in Statistics from Cornell University and is a Fellow of the American Statistical Association. Her statistical research interests include biomarker-driven clinical trial design, analysis methods for high-dimensional omics data, multiple comparisons methods, surrogate endpoints, measurement error adjustment methods, and biomarker assay analytical performance assessment. She co-led efforts to develop "Reporting guidelines for tumor marker prognostic studies (REMARK)" and "Criteria for the use of omics-based predictors in clinical trials." She is a coauthor of numerous statistical and biomedical papers and the book Statistical Design and Analysis of DNA Microarray Investigations.

Dr. McShane serves on the Scientific Advisory Board for Science Translational Medicine and is a member of the Editorial Board for BMC Medicine. She has served on several American Society of Clinical Oncology panels and committees, including those that developed guidelines for HER2 and hormone receptor testing in breast cancer, EGFR mutation testing in lung cancer, and use of tumor biomarkers in early stage breast cancer. She has served as a member of the Institute of Medicine Committee for Management of the Air Force Health Study Data and Specimens, the Consensus Committee on Management of the Air Force Health Study Data and Specimens-Report to Congress, and the Committee on the State of the Science in Ovarian Cancer Research.


Kathy Partin, Ph.D. is the Director of the Office of Research Integrity (ORI) at the U.S. Department of Health & Human Services. Dr. Partin earned her undergraduate degree in history from the University of Michigan, and her doctorate in microbiology from the State University of New York at Stony Brook. She completed postdoctoral training at Duke University studying pathophysiology of HIV and the NIH National Institute of Child Health studying neurophysiology. Following her training, Dr. Partin joined the faculty of the Department of Biomedical Sciences at Colorado State University where she performed NIH-funded basic research on ionotropic glutamate receptor structure and function for nearly twenty years. In 2007, she was appointed to the position of Director of the Research Integrity & Compliance Review Office, overseeing IRB, IBC, IACUC, GxP research and the Responsible Conduct of Research program at CSU. She served as the Assistant to the Research Integrity Officer until 2013, when she was appointed as the CSU RIO and Vice President for Research, overseeing Laboratory Animal Resources and Export Control.  Dr. Partin has taught RCR to undergraduate students, graduate students, postdoctoral fellows and faculty for many years, and has been active in the Association for Practical and Professional Ethics and the Association of Research Integrity Officers.

Local Experts

Professor Thomas E. Cheatham, III is in the Department of Medicinal Chemistry in the College of Pharmacy and also Director of Research Computing and the Center for High Performance Computing (CHPC), University Information Technology, at the University of Utah. His research takes advantage of large scale computational resources, both on the NSF Extreme Science and Engineering discovery Environment (XSEDE) and Blue Waters Petascale resources to give insight into biomolecular structure and dynamics. A focus is on using ensembles of molecular simulations to reproducibly converge the conformational distributions of biomolecules. At CHPC, in addition to providing broad support for research computing on campus, we partner with other institutions in the region and country to share expertise and resources. Cheatham received a B.A in Chemistry and a B.A. in Mathematics and Computer Science from Middlebury College, worked as programmer/analyst at Harvard University, went to the University of California at San Francisco where he received a PhD in Pharmaceutical Chemistry, and then did a NRC postdoctoral fellowship at the NIH before coming to Utah in 2000. More information is available at:


J. Michael Dean, MD, MBA is the H.A. and Edna Benning Presidential Professor of Pediatrics and Vice Chairman for Research of the Department of Pediatrics at the University of Utah School of Medicine, where he has worked since 1987. He attended Northwestern University Medical School and performed his pediatric residency and chief residency at the Children’s Hospital of Los Angeles. Prior to arrival in Utah, Dr. Dean was an Assistant Professor at The Johns Hopkins Hospital in Baltimore, Maryland, where he finished his critical care fellowship training in 1981. He received an M.B.A. from The Wharton School at the University of Pennsylvania in 1999. In Utah, Dr. Dean has served as Chief of the Division of Critical Care, Chairman of the Department of Pediatrics, Medical Director of the Primary Children’s Medical Center, Medical Director of Quality Assurance, and the Principal Investigator for numerous EMSC related grants beginning in 1991. He has published over 160 publications, served on the Critical Care Sub-Board of the American Board of Pediatrics, and as a senior editor of Pediatric Critical Care Medicine. He currently is Principal Investigator for the Data Coordinating Centers for the Pediatric Emergency Care Applied Research Network (PECARN), the NICHD funded Collaborative Pediatric Critical Care Research Network (CPCCRN), the NHLBI funded Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) Trials; the NICHD funded Pediatric Critical Care and Trauma Scientist Development (PCCTSDP) K12 Program; and most recently, a co-PI for the one of the newly-awarded NCATS Trial Innovation Center. He lives with his wife in Salt Lake City, Utah.


Dr. Tom Greene, Professor in the Division of Epidemiology in the Department of Internal Medicine, is the SDBC Director and is responsible for all aspects of the Core. Dr. Greene has served as the lead statistician at the Data Coordinating Centers for numerous multicenter clinical trials and longitudinal cohort studies, including many of the multicenter NIH sponsored clinical trials that have been performed in the field of Nephrology since 1990. Dr. Greene’s research interests include longitudinal data analysis, multivariate analysis, clinical trial design, causal modeling, and general problems in the joint analysis of longitudinal and time-to-event data including the validation of surrogate endpoints.



Mellanye Lackey is the Associate Director of Education and Research at the Spencer S. Eccles Health Sciences Library at the University of Utah in Salt Lake City, UT. Prior to her current position, Mellanye was the Public Health Information Specialist at the University of North Carolina, Chapel Hill. Mellanye provides expertise on how to conduct high quality, reproducibile systematic reviews, with an emphasis on interdisciplinary topics. She has participated in and consulted extensively on systematic reviews and meta-analyses in public health, health policy, quality improvement and global health. Mellanye represents the Systematic Review Core at the University of Utah.


Bernie LaSalle began a career of informatics and technology implementation when he joined the University of Utah General Clinical Research Center (GCRC) in 1986. “During the last 30 years the technology landscape has changed and expanded dramatically - my focus has always been on improving clinical research and health outcomes through the implementation of the best technologies, standards and practices”.  Bernie has worked with many NIH centers and institutes, pharmaceutical and device companies, and collaborates with clinical and translational researchers to transform data into reusable and sustainable information sources.

Journal Editors

John C. Carey, MD, MPH, is Professor and formerly Vice Chair of Academic Affairs, Department of Pediatrics, at the University of Utah. Throughout his career, Dr. Carey has been interested in birth defect syndromes and the care of children with these conditions. Dr. Carey graduated from Villanova University in 1968 with an A.B. and obtained his M.D. from Georgetown University School of Medicine in 1972. He trained in pediatrics, genetics and dysmorphology as a resident and fellow at the University of California San Francisco, 1972-1979. Dr. Carey obtained an M.P.H. from the University of California at Berkeley in 1976 in between his residency and fellowship years. Dr. Carey joined the faculty at University of Utah Health Sciences Center in 1979. He became Chief of the Division of Medical Genetics in 1985 and remained in that leadership position until 1999 when he stepped down to assume the role as Editor-in-Chief of the American Journal of Medical Genetics. He has held that editorial position since 2001. Dr. Carey established the Medical Genetics Fellowship Program at the University of Utah in 1985 and was the Program Director until he stepped down in 2014 but continues as a mentor and teacher in the Program.

Dr. Carey’s research focus has been in congenital malformations, neurofibromatosis, and syndrome delineation. He has authored or co-authored over 300 papers, chapters, invited articles, and editorials for scientific journals. He also co-authored the textbook, “Medical Genetics,” by Jorde, Carey, & Bamshad, now in its 5th edition. The book is a widely used text in schools of medicine throughout North America, South America, and Europe.

Dr. Carey has served as medical adviser and “founding professional” for the Support Organization for Trisomy 18, 13 and Related Disorders (SOFT) since 1980. The medical and ethical aspects of care of infants and children with these conditions are currently his major academic interest.


Julie Fritz is a Distinguished Professor in the Department of Physical Therapy and the Associate Dean for Research in the College of Health at the University of Utah.  Her research interests have focused on clinical trials and health services research related to patients with musculoskeletal conditions. Her research has been funded by the National Institutes of Health, the Agency for Healthcare Research and Quality, Department of Defense and the Physical Therapy Foundation. She has served as a grant reviewer for the NIH, PCORI and Veterans’ Administration.  Dr. Fritz is currently an Editor of the Journal of Orthopedic and Sports Physical Therapy, and an Editorial Board Member of the European Spine Journal as well as a member of the Cochrane Collaboration Back Review Group.


David W. Grainger is the University Distinguished Professor and George S. and Dolores Doré Eccles Presidential Endowed Chair in Pharmaceutics and Pharmaceutical Chemistry, and Professor of Bioengineering at the University of Utah, USA. Grainger’s research focuses on improving drug delivery methods, implanted medical device and diagnostics performance, and nanomaterials toxicity.  Grainger has published 187 research papers and 24 book chapters on biomaterials innovation in medicine and biotechnology, and novel surface and diagnostics chemistry.  HIs research awards include a 2016 Fulbright Scholar Award (New Zealand), the 2013 Excellence in Surface Science Award (Surfaces in Biomaterials Foundation), the 2007 Clemson Award for Basic Research (Society for Biomaterials), and the 2005 American Pharmaceutical Research and Manufacturer’s Association’s award for “Excellence in Pharmaceutics”. Grainger has served as Chair of several of NIH’s prominent research review panels and now serves on the NIH Council.  He serves on the editorial boards for 6 major journals, is an editor for the journal, Biomaterials, for nearly two decades, and a special topics editor for Advanced Drug Delivery Reviews.  Grainger has also won numerous teaching awards and has provided over 360 invited lectures and student workshops globally.


Patricia G. Morton, PhD, RN, ACNP-BC, FAAN joined the University of Utah in August 2013 as the Dean of the College of Nursing. She is a tenured professor and holds the Louis H. Peery Presidential Endowed Chair.

Prior to her position at the University of Utah, Dr. Morton was a member of the faculty of the University of Maryland School of Nursing. She taught in the baccalaureate, master’s and doctoral programs and held numerous administrative positions including Assistant Dean for the Master’s Program and the Associate Dean for Academic Affairs. Dr. Morton practiced as an acute care nurse practitioner at the University of Maryland Medical Center until she left her position in July of 2013.

Dr. Morton is an educator and scholar and is known for her work in critical care nursing and nursing education. She has authored three textbooks, numerous book chapters, and over 50 journal articles. She has served on the editorial board of six nursing journals and for seven years was the editor of the journal AACN Clinical Issues: Advanced Practice in Acute and Critical Care sponsored by the American Association of Critical-Care Nurses. Currently, Dr. Morton is the editor of the Journal of Professional Nursing  sponsored by the American Association of Colleges of Nursing. She has presented many papers at regional, national, and international conferences.

Dr. Morton is a member of the University of Utah Hospitals and Clinics (UUHC) Board of Trustees and the UUHC Health Care Executive Committee, and a fellow in the American Academy of Nursing.


          Spencer S. Eccles Health Sciences Library       Vice President for Research

Mayden Lecture       InfoFair & Snyder Lecture

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