According to the Centre for Evidence Based Medicine (CEBM), well-formed clinical questions are essential in practicing EBM. "." - CEBM, University of Oxford, Asking Focused Questions
Define the question to be answered using the PICO model.
Ask a clinical question using PICO model,
The PICO model allows you to formulate an answerable question.
There are several types of research questions which lend themselves to types of studies.
|Type of Question||Type of Study|
|Therapy||RCT | Cohort Study|
|Diagnosis||Prospective, blind controlled trial comparison to gold standard|
|Prevention||RCT | Cohort Study | Case Control|
|Prognosis||Cohort Study | Case Control | Case Series/Case Report|
|Etiology / Harm||Cohort Study | Case Control | Case Series|
|Cost analysis||economic analysis|
|Note: Meta-analyses and systematic reviews, when available, often provide the best answers to clinical questions|
The pyramid of evidence illustrates the hierarchy of literature and evidence.